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Estradiol Valerate
Estradiol Drug information Generic Name: estradiol (topical) (ess tra DYE ole) Brand Names: Estrace Vaginal Cream, Estring What is the most important information I should know about estradiol? Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using estradiol. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol. Do not use this medication if you are pregnant. The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate. The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. What is estradiol? Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall. Estradiol topical is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination. Estradiol may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before using estradiol? Do not use estradiol without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Using estradiol may be dangerous in some cases if you have any of the conditions listed above. Before using estradiol, tell your doctor if you have high blood pressure, angina, or heart disease; high levels of cholesterol or triglycerides in your blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; had a hysterectomy (uterus removed); a narrow, short, or prolapsed vagina; vaginal irritation; or a vaginal infection. You may not be able to use estradiol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate. The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. Estradiol is in the FDA pregnancy category X. This means that estradiol will cause birth defects in an unborn baby. Do not use estradiol if you are pregnant or are planning a pregnancy. Estradiol may decrease milk flow and have other effects on milk composition. Do not use estradiol without first talking to your doctor if you are breast-feeding a baby. How should I use estradiol? Use estradiol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. To use the Estring vaginal ring: Squeeze the sides of the ring together and insert it into the vagina as far as possible (into the upper 1/ 3 of the vagina). You should not be able to feel the ring once it is in position. If you can feel it, use a finger to push it further into the vagina. It is not possible for the ring to go too far in or become lost. The ring should remain in place for 90 days. It should then be removed and replaced by a new ring, if prescribed by your doctor. If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it. The ring does not need to be removed during sexual intercourse. It should not be felt by either partner. If it is bothersome, it can be removed, rinsed with warm water, and reinserted following intercourse. To remove the ring, loop a finger through the ring and gently pull it from the vagina. To use the estradiol vaginal cream: Using the marked applicator provided, measure the prescribed dose of cream. Lie on your back with your knees drawn up, sit, or stand in a position that allows you comfortable access to the vaginal area. To deliver the medication, gently insert the applicator deeply into your vagina and press the plunger downward to its original position. Clean the applicator by pulling the plunger to remove it from the barrel. Wash it with mild soap and warm water. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol. Store the vaginal rings and cream at room temperature away from moisture and heat. What happens if I miss a dose? Insert the next dose of cream or ring as soon as you remember. Continue to follow your regular schedule. Do not use two doses simultaneously unless your doctor directs otherwise. If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it. What happens if I overdose? An overdose of estradiol is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if the medication has been ingested, call an emergency room or poison control left for advice. What should I avoid while using estradiol? There are no restrictions on food, beverages, or activity while using estradiol unless your doctor directs otherwise. What are the possible side effects of estradiol? Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using estradiol. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. If you experience any of the following serious side effects, stop using estradiol and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to use estradiol and talk to your doctor if you experience decreased appetite, nausea, or vomiting; swollen breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; vaginal pain, dryness, or discomfort; water retention (swollen hands, feet, or ankles); depression; or changes in your menstrual cycle or break-through bleeding. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect estradiol? Before using estradiol, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; or tamoxifen (Nolvadex). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Do not use other vaginal products at the same times as estradiol without first talking to your doctor. Drugs other than those listed here may also interact with estradiol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Evista
Evista This page contains drug information on Evista. The information provided includes the following: what is Evista the possible side effects of Evista what happens if you miss a dose of Evista what happens if you overdose with Evista the most important information about Evista how to use Evista other drugs that may affect Evista what to avoid while using Evista Generic Name: raloxifene (oral) (rah LOX ih feen) Brand Names: Evista What is the most important information I should know about raloxifene? Do not take raloxifene if you are pregnant or if you could become pregnant during treatment. Raloxifene is in the FDA pregnancy category X. This means that raloxifene is known to cause birth defects in an unborn baby. Before having any surgery, tell your doctor that you are taking raloxifene. Treatment with raloxifene may need to be stopped temporarily if you require an extended period of bed rest. Avoid sitting still for long periods of time during travel while taking raloxifene. Seek immediate medical attention if you experience and of the following side effects that may indicate a blood clot formation: sharp pain in the legs; swelling of the legs; sudden chest pain; coughing up blood; or changes in vision. What is raloxifene? Raloxifene alters the cycle of bone formation and breakdown in the body. It reduces loss of bone tissue. Although studies are not complete, raloxifene appears to work without increasing the risk of breast or uterine cancer. Raloxifene is used to treat and prevent osteoporosis (decreased density of bone mass) in postmenopausal women. Raloxifene may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking raloxifene? Before having any surgery, tell your doctor that you are taking raloxifene. Treatment with raloxifene may need to be stopped temporarily if you require an extended period of bed rest. Before taking this medication, tell your doctor if you have a history of blood clots; stroke; cancer; increased triglycerides (a type of fat in the blood); or liver disease. You may not be able to take raloxifene, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Raloxifene is in the FDA pregnancy category X. This means that raloxifene is known to cause birth defects in an unborn baby. Do not take raloxifene if you are pregnant or if you could become pregnant during treatment. It is not known whether raloxifene passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. How should I take raloxifene? Take raloxifene exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Raloxifene can be taken with or without food. Take raloxifene at the same time each day. Your doctor may want you to take calcium and vitamin D supplements if you do not receive enough of these substances from your regular diet. Weight-bearing exercise may also be helpful. Store raloxifene at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. What happens if I overdose? Seek medical attention. Symptoms of a raloxifene overdose are not known. What should I avoid while taking raloxifene? Before having any surgery, tell your doctor that you are taking raloxifene. Treatment with raloxifene may need to be stopped temporarily if you require an extended period of bed rest. Avoid sitting still for long periods of time during travel while taking raloxifene. Alcohol and cigarette smoking may cause increased bone loss. Discuss with your doctor the use of these products. What are the possible side effects of raloxifene? If you experience any of the following serious side effects, stop taking raloxifene and seek emergency medical attention or notify your doctor: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); sharp pain in the legs; swelling of the legs; sudden chest pain; coughing up blood; changes in vision; or unexplained vaginal bleeding. Other, less serious side effects may be more likely to occur. Continue to take raloxifene and talk to your doctor if you experience leg cramps, muscle soreness, weight gain, sweating, hot flashes, or a rash. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect raloxifene? Before taking raloxifene, talk to your doctor if you are taking any of the following medicines: cholestyramine (Questran, Prevalite) or colestipol (Colestid); the blood thinner warfarin (Coumadin); or an estrogen or progesterone product such as birth control pills or hormone replacement therapy. You may not be able to take raloxifene, or you may require special monitoring or a dosage adjustment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with raloxifene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Ovral-G
Ovral This page contains drug information on Ovral. The information provided includes the following: what is Ovral the possible side effects of Ovral what happens if you miss a dose of Ovral what happens if you overdose with Ovral the most important information about Ovral how to use Ovral other drugs that may affect Ovral what to avoid while using Ovral Generic Name: ethinyl estradiol and norgestrel (EH thin nil Ess try DYE ole and nor JESS tael) Brand Names: Lo/ Ovral, Lo/ Ovral-28, Low-Ogestrel, Ogestrel, Ovral, Ovral-28 What is the most important information I should know about birth control pills? Take your pill at the same time every day. Each dose should come no more than 24 hours after the last dose. Avoid smoking cigarettes while taking birth control pills. Smoking greatly increases the risk of heart attack, stroke, or blood clot formation while using birth control pills. Use another form of birth control if you miss several doses (see the package insert) or if you are taking drugs that decrease the effectiveness of birth control pills (see the section of this leaflet titled "What other drugs will affect birth control pills?"). What are birth control pills? Birth control pills contain a combination of hormones that is used to prevent ovulation (the release of an egg from an ovary). The pills contain a form of estrogen and a form of progesterone, which are both female hormones involved in conception. Birth control pills also have other effects that inhibit pregnancy. They cause the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus, and they prevent the attachment of an egg to the uterus. Birth control pills are used to prevent pregnancy. Birth control pills may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking birth control pills? Before taking birth control pills, tell your doctor if you have high blood pressure, angina, or heart disease; have had a stroke; have a bleeding or blood-clotting disorder; have breast, uterine, or another hormone-related cancer; have liver disease or a history of jaundice (yellowing of the skin and eyes) caused by use of birth control in the past; have undiagnosed, abnormal vaginal bleeding; have migraines; have asthma; or have seizures or epilepsy. You may not be able to take birth control pills, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. Birth control pills are in the FDA pregnancy category X. This means that birth control pills will cause birth defects in an unborn baby. Hormonal changes during pregnancy can have very serious negative effects on a developing baby. Do not take birth control pills if you are pregnant or if you think you might be pregnant. The hormones in birth control pills pass into breast milk and may decrease milk production. Do not take birth control pills without first talking to your doctor if you are breast-feeding a baby. How should I take my birth control pills? Take your birth control pills exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take the first pill in a package on the first Sunday after your period begins (unless otherwise directed by your doctor). Take one pill every day, no more than 24 hours after your last dose. Try to take the pills at a time that you will remember every day--for example, just before bed, with a meal, or first thing in the morning. Taking your pill at night may help to reduce any nausea or headache that you may experience because of the hormones. If you are on a 28-day cycle, take one pill every day. When the pack runs out, throw it away. Begin a new pack the following day. The 28-day cycle contains seven pills that are either placebos (with no active ingredients) or iron supplements. These are "reminder" pills to keep you on your regular cycle. They are taken while you are menstruating. If you are on a 21-day cycle, take one pill every day for 21 days, then do not take any pills for 7 days. You should have your period during the 7 days with no pills. Resume your pills on the 8th day with a new package. Follow your doctor's instructions about using a second form of birth control when you first start taking birth control pills, when you are taking antibiotics, or if you miss a pill. If you are unsure what to do in any of these cases, talk to your pharmacist, nurse, or doctor about how to ensure that you will not become pregnant. Store birth control pills at room temperature away from moisture and heat. What happens if I miss a dose? Missing a pill increases the risk of becoming pregnant. Follow the exact directions on your package information insert concerning missed doses. If you do not have a package information insert, call your pharmacist, doctor, or nurse to find out what to do. In general: If you miss one dose, take it as soon as you remember or take two pills at the time of your next regularly scheduled dose. There is little likelihood that ovulation will occur. You may, however, want to use a second method of birth control such as a condom or a spermicidal cream, jelly, or foam for at least seven consecutive days following the missed tablet to ensure protection from pregnancy. If you miss two tablets in a row, take the two missed tablets as soon as you remember or with your next regularly scheduled dose (three total). Or, you may take two tablets each for the next two regularly scheduled doses (one missed tablet plus one regularly scheduled tablet for two days in a row). Chances are much greater that you may ovulate so you must use another form of birth control for at least 7 days following the missed tablets. It is even better to use a second method of birth control until your next period. If you miss three tablets in a row, throw away the package and start a new package on the 7th day after the last day you took a pill. Use another method of birth control until you have taken a pill for 7 days in a row. Your period should occur during the 7 days without pills. If it doesn't, have a pregnancy test before beginning a new package of pills. Read all of the information in your package information insert. It may have slightly different instructions in the case of missed pills. Talk to your pharmacist, nurse, or doctor if you have any questions. What happens if I overdose? Death is not likely to occur from an overdose of birth control pills. Consult a doctor, an emergency room, or a poison controlleft for advice. Symptoms of an overdose include nausea, vomiting, and menstrual bleeding in females. What should I avoid while taking my birth control pills? Avoid smoking. It greatly increases your risk of a heart attack, stroke, or blood clot formation. Birth control pills do not protect you from sexually transmitted diseases--including HIV and AIDS. What are the possible side effects of my birth control pills? If you experience any of the following serious side effects, stop taking your birth control pills and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); a blood clot in the lung (shortness of breath or pain in the chest); a blood clot in an arm or leg (pain, redness, swelling, or numbness of an arm or leg); high blood pressure (severe headache, flushing, blurred vision); or liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue). Other, less serious side effects may be more likely to occur. Continue to take your birth control pills and talk to your doctor if you experience headache or dizziness; nausea, vomiting, or diarrhea; breakthrough bleeding; or breast tenderness. These side effects may disappear or be less noticeable after 3 to 6 months of birth control use. Ask your doctor or pharmacist for advice if you find any side effect very bothersome. The side effects listed below generally occur very rarely and are not considered serious. If you experience any of the following, talk to your doctor: depression, changes in weight or appetite, vaginal yeast infection, changes in your menstrual cycle, oily skin or acne, changes in your sex drive, lethargy or fatigue, bloating, changes in your skin color, or changes in your blood sugar. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect my birth control pills? Some drugs may decrease the effectiveness of birth control pills, which may result in pregnancy. Use a second form of birth control if you are taking a penicillin antibiotic such as amoxicillin (Amoxil, Polymox, Trimox, Wymox, Utimox, A-Cillin, Larotid, Augmentin, others), ampicillin (Principen, Omnipen, Penamp, Polycillin, Amplin, Amcill, Totacillin, others), bacampicillin (Spectrobid), carbenicillin (Geocillin), cloxacillin (Cloxapen, Tegopen), dicloxacillin (Dynapen, Dycill, Pathocil), nafcillin (Nafcil, Nallpen, Unipen), oxacillin (Bactocill, Prostphlin), or penicillin (Veetids, Pen Vee K, Bicillin, Permapen, others); a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Doryx, Doxy, Vibramycin, Vibra-Tabs, others), minocycline (Minocin), or tetracycline (Sumycin, Teracyn, Achromycin, Robitet, Panmycin, others); a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); rifampin (Rifadin); phenytoin (Dilantin); carbamazepine (Tegretol); or griseofulvin (Grisactin, Grifulvin V, Fulvicin PG). Drugs other than those listed here may also interact with birth control pills. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Ovral-L

Premarin
Premarin This page contains drug information on Premarin. The information provided includes the following: what is Premarin the possible side effects of Premarin what happens if you miss a dose of Premarin what happens if you overdose with Premarin the most important information about Premarin how to use Premarin other drugs that may affect Premarin what to avoid while using Premarin Generic Name: conjugated estrogens (CON jew gay ted ESS troe jenz) Brand Names: Cenestin, Premarin What is the most important information I should know about conjugated estrogens? Conjugated estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with conjugated estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with conjugated estrogens may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, conjugated estrogens should be prescribed at the lowest effective dose, for the shortest amount of time necessary. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogens. Do not take conjugated estrogens if you are pregnant. What are conjugated estrogens? Estrogen is a female sex hormone necessary for many processes in the body. Conjugated estrogens are used to treat symptoms of menopause; deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility); some types of breast cancer in men and in postmenopausal women; degeneration of the vagina; and urethra and prostate cancer. In addition, conjugated estrogens are used to prevent osteoporosis. Conjugated estrogens may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking conjugated estrogens? Do not take conjugated estrogens without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Taking conjugated estrogens may be dangerous in some cases if you have any of the conditions listed above. Before taking conjugated estrogens, tell your doctor if you have high blood pressure, angina, or heart disease; high levels of cholesterol or triglycerides in the blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; or had a hysterectomy (uterus removed). You may not be able to take conjugated estrogens, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Conjugated estrogens are in the FDA pregnancy category X. This means that conjugated estrogens are known to cause birth defects in an unborn baby. Do not take this medication if you are pregnant or could become pregnant during treatment. Conjugated estrogens may decrease milk flow and have other effects on milk composition. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. How should I take conjugated estrogens? Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take conjugated estrogens with food or milk to lessen stomach upset. Try to take doses at the same time daily. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogens. It is important to take conjugated estrogens regularly to get the most benefit. Your doctor may want you to have blood tests or other medical evaluations during treatment with conjugated estrogens to monitor progress and side effects. Store conjugated estrogens at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember then return to your regular dosing schedule. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? An overdose of this medication is unlikely to threaten life. Consult an emergency room or poison control left for advice. Symptoms of an overdose of conjugated estrogens include nausea, vomiting, and vaginal bleeding in females. What should I avoid while taking conjugated estrogens? There are no restrictions on food, beverages, or activity while taking conjugated estrogens unless your doctor directs otherwise. What are the possible side effects of conjugated estrogens? Conjugated estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with conjugated estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with conjugated estrogens may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, conjugated estrogens should be prescribed at the lowest effective dose, for the shortest amount of time necessary. If you experience any of the following serious side effects, stop taking conjugated estrogens and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, or swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to take conjugated estrogens and talk to your doctor if you experience decreased appetite, nausea, or vomiting; swollen or tender breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; water retention (swollen hands, feet, or ankles); problems with wearing contact lenses; depression; or changes in menstrual cycle or breakthrough bleeding. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect conjugated estrogens? Before taking conjugated estrogens, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others); insulin or an oral diabetes medicine such as glipizide (Glucotrol) or glyburide (Diabeta, Micronase); tamoxifen (Nolvadex); didanosine (Videx); phenytoin (Dilantin) or ethotoin (Peganone); carbamazepine (Tegretol); phenobarbital (Solfoton, Luminal); primidone (Mysoline); or rifampin (Rifadin). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with conjugated estrogens. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Premarin Cream
Premarin This page contains drug information on Premarin. The information provided includes the following: what is Premarin the possible side effects of Premarin what happens if you miss a dose of Premarin what happens if you overdose with Premarin the most important information about Premarin how to use Premarin other drugs that may affect Premarin what to avoid while using Premarin Generic Name: conjugated estrogens (CON jew gay ted ESS troe jenz) Brand Names: Cenestin, Premarin What is the most important information I should know about conjugated estrogens? Conjugated estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with conjugated estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with conjugated estrogens may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, conjugated estrogens should be prescribed at the lowest effective dose, for the shortest amount of time necessary. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogens. Do not take conjugated estrogens if you are pregnant. What are conjugated estrogens? Estrogen is a female sex hormone necessary for many processes in the body. Conjugated estrogens are used to treat symptoms of menopause; deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility); some types of breast cancer in men and in postmenopausal women; degeneration of the vagina; and urethra and prostate cancer. In addition, conjugated estrogens are used to prevent osteoporosis. Conjugated estrogens may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking conjugated estrogens? Do not take conjugated estrogens without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Taking conjugated estrogens may be dangerous in some cases if you have any of the conditions listed above. Before taking conjugated estrogens, tell your doctor if you have high blood pressure, angina, or heart disease; high levels of cholesterol or triglycerides in the blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; or had a hysterectomy (uterus removed). You may not be able to take conjugated estrogens, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Conjugated estrogens are in the FDA pregnancy category X. This means that conjugated estrogens are known to cause birth defects in an unborn baby. Do not take this medication if you are pregnant or could become pregnant during treatment. Conjugated estrogens may decrease milk flow and have other effects on milk composition. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. How should I take conjugated estrogens? Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take conjugated estrogens with food or milk to lessen stomach upset. Try to take doses at the same time daily. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogens. It is important to take conjugated estrogens regularly to get the most benefit. Your doctor may want you to have blood tests or other medical evaluations during treatment with conjugated estrogens to monitor progress and side effects. Store conjugated estrogens at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember then return to your regular dosing schedule. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? An overdose of this medication is unlikely to threaten life. Consult an emergency room or poison control left for advice. Symptoms of an overdose of conjugated estrogens include nausea, vomiting, and vaginal bleeding in females. What should I avoid while taking conjugated estrogens? There are no restrictions on food, beverages, or activity while taking conjugated estrogens unless your doctor directs otherwise. What are the possible side effects of conjugated estrogens? Conjugated estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with conjugated estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with conjugated estrogens may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, conjugated estrogens should be prescribed at the lowest effective dose, for the shortest amount of time necessary. If you experience any of the following serious side effects, stop taking conjugated estrogens and seek emergency medical attention: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); shortness or breath or pain in the chest; a painful, red, or swollen leg; abnormal vaginal bleeding; pain, swelling, or tenderness in the abdomen; severe headache or vomiting, dizziness, faintness or changes in vision or speech; yellowing of the skin or eyes; or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to take conjugated estrogens and talk to your doctor if you experience decreased appetite, nausea, or vomiting; swollen or tender breasts; acne or skin color changes; decreased sex drive; migraine headaches or dizziness; water retention (swollen hands, feet, or ankles); problems with wearing contact lenses; depression; or changes in menstrual cycle or breakthrough bleeding. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect conjugated estrogens? Before taking conjugated estrogens, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); a thyroid medication such as levothyroxine (Synthroid, Levoxyl, Levothroid, and others); insulin or an oral diabetes medicine such as glipizide (Glucotrol) or glyburide (Diabeta, Micronase); tamoxifen (Nolvadex); didanosine (Videx); phenytoin (Dilantin) or ethotoin (Peganone); carbamazepine (Tegretol); phenobarbital (Solfoton, Luminal); primidone (Mysoline); or rifampin (Rifadin). A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with conjugated estrogens. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Premphase
Premphase This page contains drug information on Premphase. The information provided includes the following: what is Premphase the possible side effects of Premphase what happens if you miss a dose of Premphase what happens if you overdose with Premphase the most important information about Premphase how to use Premphase other drugs that may affect Premphase what to avoid while using Premphase Generic Name: conjugated estrogen and medroxyprogesterone combinations (ESS troe jen and me DROX ee proe JESS te rone) Brand Names: Premphase, Prempro What is the most important information I should know about conjugated estrogen and medroxyprogesterone combinations? Conjugated estrogens increase the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Taking a progestin, such as medroxyprogesterone, with conjugated estrogens lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. The Women's Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, nonfatal heart attacks, and blood clots in women taking estrogen and medroxyprogesterone combinations long-term. You should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking a conjugated estrogen and medroxyprogesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking conjugated estrogen and medroxyprogesterone combinations. Do not take conjugated estrogen and medroxyprogesterone combinations if you are pregnant or planning to become pregnant. It could affect the development of the baby. What are conjugated estrogen and medroxyprogesterone combinations? Conjugated estrogens are naturally occurring female sex hormones that are involved in the development and maintenance of the female reproductive system. Medroxyprogesterone is a female hormone, usually called "progesterone." It is important for the regulation of ovulation and menstruation. Together, conjugated estrogen and progesterone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating ("hot flashes" or "hot flushes"); to treat vulvar and vaginal changes caused by menopause (itching, burning, dryness in or around the vagina, difficulty or burning with urination); and to prevent thinning of the bones (osteoporosis). Conjugated estrogen and medroxyprogesterone combinations may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking conjugated estrogen and medroxyprogesterone combinations? Do not take conjugated estrogen and medroxyprogesterone combinations without first talking to your doctor if you have had an allergic reaction to another estrogen or progesterone product; a circulation, bleeding, or blood-clotting disorder; a history of blood clots in the leg or lung; liver disease; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Taking conjugated estrogen and medroxyprogesterone combinations may be dangerous in some cases if you have any of the conditions listed above. Before taking conjugated estrogen and medroxyprogesterone combinations, tell your doctor if you have high blood pressure, angina, or heart disease; a history of heart attack or stroke; high levels of cholesterol or triglycerides in the blood; kidney disease; thyroid problems; asthma; epilepsy; migraines; depression; diabetes; gallbladder disease; uterine fibroids; or had a hysterectomy (uterus removed). You may not be able to take conjugated estrogen and medroxyprogesterone combinations, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. The Women's Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, nonfatal heart attacks, and blood clots in women taking estrogen and medroxyprogesterone combinations long-term. You should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking a conjugated estrogen and medroxyprogesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Conjugated estrogen and medroxyprogesterone combinations are in the FDA pregnancy category X. This means that these medications are known cause birth defects in an unborn baby. Do not take conjugated estrogen and medroxyprogesterone combinations if you are pregnant or if you could become pregnant during treatment. Conjugated estrogen and medroxyprogesterone combinations pass into breast milk, and the effects on a nursing infant are unknown. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. How should I take conjugated estrogen and medroxyprogesterone combinations? Take conjugated estrogen and medroxyprogesterone combinations exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take conjugated estrogen and medroxyprogesterone combinations with food or milk to lessen stomach upset. Try to take doses at the same time each day. You may be taking the medication on a cycle, such as every day for 3 weeks with 1 week off each month to mimic the body's natural cycle. Follow the directions on the prescription label. Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking a conjugated estrogen and medroxyprogesterone combination. It is important to take conjugated estrogen and medroxyprogesterone combinations regularly to get the most benefit. Your doctor may want you to have blood tests or other medical evaluations during treatment with a conjugated estrogen and medroxyprogesterone combination to monitor progress and side effects. Store conjugated estrogen and medroxyprogesterone combinations at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and return to the regular dosing schedule. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? An overdose of a conjugated estrogen and medroxyprogesterone combination is unlikely to threaten life. Call an emergency room or poison control left for advice if an overdose is suspected. Symptoms of a conjugated estrogen and medroxyprogesterone combination overdose might include nausea, vomiting, and vaginal bleeding. What should I avoid while taking conjugated estrogen and medroxyprogesterone combinations? There are no restrictions on food, beverages, or activity while taking a conjugated estrogen and medroxyprogesterone combination unless your doctor directs otherwise. What are the possible side effects of conjugated estrogen and medroxyprogesterone combinations? Conjugated estrogens increase the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Taking a progestin, such as medroxyprogesterone, with conjugated estrogens lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. The Women's Health Initiative (WHI) study found an increased risk of breast cancer, heart disease, nonfatal heart attacks, and blood clots in women taking estrogen and medroxyprogesterone combinations long-term. You should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking a conjugated estrogen and medroxyprogesterone combination long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment. Stop taking the conjugated estrogen and medroxyprogesterone combination and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); a blood clot (pain, redness, and swelling in an arm or leg; shortness of breath; coughing blood; chest pain; headache; blurred vision; confusion; loss of speech, or dizziness); unusual or abnormal vaginal bleeding; gallbladder disease (pain, swelling, or tenderness in the abdomen); liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or a lump in a breast. Other, less serious side effects may be more likely to occur. Continue to take conjugated estrogen and medroxyprogesterone combinations and talk to your doctor if you experience changes in appetite or weight, changes in blood sugar levels; swelling of the hands or feet, tiredness or weakness, irregular bleeding or spotting, depression, an increase in body or facial hair or hair loss, swollen or tender breasts, nausea, headache or insomnia, changes in your voice, or areas of darker skin. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect conjugated estrogen and medroxyprogesterone combinations? Before taking a conjugated estrogen and medroxyprogesterone combination, tell your doctor if you are taking any of the following medicines: an anticoagulant (blood thinner) such as warfarin (Coumadin); insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase), and others; or tamoxifen (Nolvadex); A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with conjugated estrogen and medroxyprogesterone combinations. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Premphase Cycle

Provera
Provera This page contains drug information on Provera. The information provided includes the following: what is Provera the possible side effects of Provera what happens if you miss a dose of Provera what happens if you overdose with Provera the most important information about Provera how to use Provera other drugs that may affect Provera what to avoid while using Provera Generic Name: medroxyprogesterone (me DROX ee proe JESS te rone) Brand Names: Amen, Curretab, Cycrin, Provera What is the most important information I should know about medroxyprogesterone? Do not take medroxyprogesterone if you are pregnant or planning to become pregnant. It could affect the development of your baby. What is medroxyprogesterone? Medroxyprogesterone is a female hormone, usually called "progesterone". It is important for the regulation of ovulation and menstruation. Medroxyprogesterone is used to treat conditions such as irregular or abnormal uterine bleeding and lack of menstruation. Progesterone or progesterone-like drugs have been used to prevent miscarriage in the first few months of pregnancy. No adequate evidence is available to show that they are effective for this purpose. Furthermore, most cases of early miscarriage are due to causes which could not be helped by these drugs. These drugs have been used as a test for pregnancy but such use is not longer considered safe because of possible damage to a developing baby. Also, more rapid methods for testing for pregnancy are now available. The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. Medroxyprogesterone may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before taking medroxyprogesterone? Do not take medroxyprogesterone without the approval of your doctor if you have a bleeding or blood-clotting disorder, any type of breast or uterine cancer, or liver or gallbladder disease. Before taking this medication, tell your doctor if you have epilepsy or a seizure disorder, migraines, asthma, kidney disease, heart disease, or diabetes. You may not be able to take medroxyprogesterone, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above. The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy. Medroxyprogesterone is in the FDA pregnancy category D. This means that medroxyprogesterone is known to harm an unborn baby. There is an increased risk of minor birth defects in children whose mothers take this drug during the first 4 months of pregnancy. Several reports suggest an association between mothers who take these drugs in the first trimester of pregnancy and genital abnormalities in male and female babies. The risk to the male baby is the possibility of being born with a condition in which the opening of the penis is on the underside rather than the tip of the penis (hypospadias). Hypospadias occurs in about 5 to 8 per 1000 male births and about doubled with exposure to these drugs. There is not enough information to quantify the risk to exposed female fetuses, but enlargement of the clitoris and fusion of the labia may occur, although rarely. Therefore, since drugs of this type may induce mild masculinization of the external genitalia of the female fetus, as well as hypospadias in the male fetus, it is wise to avoid using the drug during the first trimester of pregnancy. Do not take this medication if you are pregnant or if you are planning a pregnancy. Detectable amounts of medroxyprogesterone enter the milk of mothers receiving medroxyprogesterone. The effect on the nursing infant has not been determined. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. How should I take medroxyprogesterone? Take medroxyprogesterone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take medroxyprogesterone with food or milk to lessen stomach upset. Try to take your doses at the same time each day. Medroxyprogesterone is usually taken for a certain number of days each month according to your body's natural cycle. Store medroxyprogesterone at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Do not take a double dose of this medication unless otherwise directed by your doctor. What happens if I overdose? A medroxyprogesterone overdose is unlikely to threaten life. Call an emergency room or poison control left for advice. Symptoms of a medroxyprogesterone overdose include nausea, vomiting, fluid retention (swelling of the hands and feet), breast discomfort, and vaginal bleeding. What should I avoid while taking medroxyprogesterone? Avoid smoking while taking medroxyprogesterone. Smoking greatly increases the risk of blood clot formation. Avoid excessive salt intake. Too much salt may cause fluid retention and discomfort. Avoid prolonged exposure to sunlight. Medroxyprogesterone may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. What are the possible side effects of medroxyprogesterone? Stop taking medroxyprogesterone and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); shortness of breath or pain in your chest; a sudden severe headache; visual changes; a painful, red, swollen leg; numbness or tingling in an arm or leg; prolonged, heavy, vaginal bleeding; stomach or side pain; or yellowing of your skin or eyes. Other, less serious side effects may be more likely to occur. Continue to take medroxyprogesterone and talk to your doctor if you experience changes in appetite or weight, swelling of your hands or feet, changes in your menstrual cycle, depression, acne, an increase in body or facial hair or hair loss, tenderness of the breasts, nausea, headache or insomnia, changes in your voice, or areas of darker skin. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect medroxyprogesterone? Before taking medroxyprogesterone, tell your doctor if you are taking any of the following medications: insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase); bromocriptine (Parlodel); aminoglutethimide (Cytadren); phenobarbital (Solfoton, Luminal); or chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), promazine (Sparine), thioridazine (Mellaril), or trifluoperazine (Stelazine). You may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with medroxyprogesterone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.